Development of new antitumor platinum complexes.
نویسندگان
چکیده
منابع مشابه
DNA interactions of new antitumor aminophosphine platinum(II) complexes.
Mechanistic studies are presented of a novel class of aminophosphine platinum(II) complexes as potential anticancer agents. These new agents, which have demonstrated activity against murine and human tumor cells including those resistant to cisplatin are cis-[PtCl2(Me2N(CH2)3PPh2-P)2] (Com1) and cis-[PtCl(C6H11NH(CH2)2PPh2-N,P)(C6H11NH(CH2) 2PPh2-P)] (Com2). We studied modifications of natural ...
متن کاملsynthesis of binuclear platinum complexes containing biphosphine ligand
هدف از این مطالعه طراحی یک روش کلی برای سنتز یک سری از کمپلکس های دو هسته ای متقارن سیکلومتاله شده پلاتین (ii) بوده که دارای یک لیگاند پل زن(1,2-bis[bis(pentafluoro-phenyl)phosphino]ethane),dfppe, است. از واکنش cis-[pt(r)2(sme2)2]، که در آنr= para-tolyl ، با یک اکی والان از لیگاند benzo[h]quinoline,bhq، در استون محصول [pt(r)(bhq)(sme2)] که در آن r= para-tolyl بدست می آید. همچنین از واکنش 5/0 اک...
Synthesis and in vitro antitumor activity of platinum acetonimine complexes.
The cis- and trans-dichloro- and diiodo-platinum(II) complexes containing two acetonimines (cis- and trans-[PtX(2){HN=C(CH(3))(2)}(2)], 1 and 2 for X = Cl and 1' and 2' for X = I, respectively) or one acetonimine and one ammine (cis- and trans-[PtX(2)(NH(3)){HN=C(CH(3))(2)}], 3 and 4 for X = Cl and 3' and 4' for X = I, respectively) have been prepared from platinum-ammine precursors by condensa...
متن کاملSynthesis and evaluation of platinum complexes with potential antitumor activity
A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cell lines. Compound 3 was selected for further s...
متن کاملAscorbato(1,2-diaminocyclohexane):platinum(ll) Complexes, a New Series of Water-soluble Antitumor Drugs1
Dichloro-1,2-diaminocyclohexane (DACH):platinum(ll), the pro totype DACH:platinum complex, had good antitumor activity, was not cross-resistant with c/'s-dichlorodiammineplatinum(ll) (DDP), but was, unfortunately, virtually insoluble in water and was, therefore, not evaluated clinically. This paper summarizes some of the chemical and biological attributes of a series of c/'sbisascorbato-DACH:pl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: NIPPON KAGAKU KAISHI
سال: 1988
ISSN: 2185-0925,0369-4577
DOI: 10.1246/nikkashi.1988.684